The study covered in this summary was published in researchsquare.com as a preprint and has not yet been peer reviewed.
Pericoronary adipose tissue (PCAT) fat attenuation index (FAI) associated with different coronary arteries was positively correlated with echocardiographic markers of left ventricular (LV) function.
The correlations were strongest for PCAT associated with the left anterior descending (LAD) coronary artery.
But PCAT was not associated with severity of coronary artery disease (CAD).
Nor was PCAT correlated with body mass index (BMI) or a range of standard CAD risk factors.
Why This Matters
Recent studies have shown that PCAT participates in the process of coronary arterial inflammation and has been associated with higher risk of cardiac mortality.
The results suggest that cardiac mortality associated with increased PCAT FAI may be due to detrimental changes in LV function.
The study supports PCAT FAI as an imaging index of coronary arterial inflammation with a significant potential role in CAD diagnosis and evaluation.
The retrospective single-center study enrolled 159 participants with clinically suspected CAD. The mean age of the patients was about 64, and 65% were men.
All participants underwent coronary CT angiography and echocardiography followed within 6 months by invasive coronary angiography.
Relationships between PCAT and CAD severity, and PCAT volume and LV function, were explored for any correlations.
Excluded from the study were patients with a history of myocardial infarction or cardiac surgery, anatomic variations in heart or coronary arteries, diseases that greatly affect cardiac function such as cardiomyopathy and heart-valve disease, a family history of CAD, or a failure of image reconstruction.
PCAT volume was not associated with Gensini score (index of CAD severity), remeron generic BMI, or standard CAD risk factors that included hypertension, diabetes, dyslipidemia, smoking, and drinking.
PCAT FAI was associated with major epicardial coronary arteries and was positively associated with echocardiographic measures of LV function, including LV end-diastolic and end-systolic dimensions and volumes and LV mass. The relationship was strongest for the LAD coronary artery.
PCAT FAI was not associated with LAD or right-coronary arterial volume or BMI.
The retrospective study was single-center with a small sample size.
Relatively few patients had severe CAD, and CAD severity was not stratified.
The study did not include information on lifestyle and treatment interventions.
Studies have shown there are differences in FAI by sex, and women and men were not equally represented. Further sex-specific variables to clarify the relationship between PCAT and LV function are needed.
The study received no commercial funding.
The authors have disclosed no relevant financial relationships.
This is a summary of a preprint research study, “The Correlation of Pericoronary Adipose Tissue With Coronary Artery Disease and Left Ventricular Function,” written by researchers at Changzhou No. 2 People’s Hospital, Changzhour, Jiangsu, China, published on ResearchSquare and provided to you by Medscape. This study has not yet been peer reviewed. The full text of the study can be found on researchsquare.com.
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