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The study was published on as a preprint and has not yet been peer reviewed.

Key Takeaway

  • By allowing higher radiation doses, intensity-modulated radiotherapy (IMRT) alongside intra-arterial cisplatin, substantially improves local control in advanced maxillary sinus cancer without an increase in adverse events compared with 3-dimensional conformal radiotherapy (3DCRT).

Why This Matters

  • Superselective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT) is an alternative to potentially disfiguring surgery. 

  • IMRT vs 3DCRT allows for higher radiation doses to the tumor while decreasing exposure to healthy tissue.  

  • The study may be the first to report the relationship between total radiation dose and treatment outcomes.

Study Design

  • Investigators reviewed 58 patients with localized maxillary sinus cancer treated with RADPLAT from 2004 to 2020.

  • Radiation was delivered by 3DCRT in 34 patients and IMRT in 24.

Key Results

  • The median prescribed dose to the local lesion was 66 Gy in the 3DCRT group and 70 Gy in the IMRT group.

  • Patients who were treated with 70 Gy using IMRT had a significantly higher local control rate (87.7%) than patients treated with 66 Gy (72.1%) or 60 Gy or below (41%).

  • The 5-year overall survival rate was 88.5% for those in 70 Gy group, 66.6% in the 66 Gy group, and 72.7% in the 60 Gy or less group.

  • One patient had grade 3 or higher eye disorder (cataracts) in the IMRT group; the authors observed four cases of blindness in the 3DCRT group.


  • No study limitations were reported.


  • There was no funding for the work, and the investigators did not report any disclosures.

This is a summary of a preprint research study, “Impact of total radiation dose on treatment outcomes of radiotherapy and concomitant superselective intra-arterial high-dose cisplatin in localized maxillary sinus cancer, side effects of amoxicillin 500mg 4 times a day ” led by Kenta Konishi of the Hamamatsu University School of Medicine, Japan. The study has not been peer reviewed. The full text can be found at

M. Alexander Otto is a physician assistant with a master’s degree in medical science and a journalism degree from Newhouse. He is an award-winning medical journalist who has worked for several major news outlets before joining Medscape and also an MIT Knight Science Journalism fellow. Email: [email protected]

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