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Personalizing cardiac medicine with models

Computational models of the heart could be a precious tool for cardiologists during diagnosis and decision making. They can help with the interpretation of a patient’s clinical measurements to discover the underlying pathology or to simulate different intervention scenarios. Typically, the model requires a personalization stage that incorporates a person’s specific heart geometry, but should ideally also include orientation of the muscle fibers. Ph.D. candidate Luca Barbarotta of the TU/e Department of Biomedical Engineering researched the impact of different choices for geometry and fiber orientation on the outcomes of the model. He successfully defended his thesis on 13 January 2021.

Personalization of heart mechanics models often includes geometrical information acquired from imaging methodologies and additional data from other patient metrics. Often, it also includes deformations and strains seen via non-invasive imaging.

In this personalization process, great attention is often put on the personalization of the geometry, whereas fiber orientation is modeled using generic rule-based models. This is mostly because in-vivo measurement of fiber orientation is still a challenge, while reconstructing patient-specific geometry is easier. Both geometry and fiber orientation data suffer from the presence of measurement noise and reconstruction errors.

First step

Barbarotta quantified the impact that different choices for the modeling of geometry and fiber orientation have on the resulting strain prediction and made a first step towards data assimilation by estimating patient-specific fiber orientation from end-systolic strain. He also proposed a methodology to estimate how sensitive end-systolic strains are to physiological variations.

He created six shape models describing the anatomy of 300 healthy hearts to represent a multitude of geometries in the neighborhood of one standard deviation around the average patient geometry. Information from two atlases of fiber orientation, obtained from ex-vivo Diffusion Tensor Imaging, was used to represent variations of one standard deviation around an average configuration.

Personalizing computational models of heart mechanics

These findings show that fiber orientation affects end-systolic strain distributions at least twice as much as geometry. The transverse angle of the fibers is the main contribution, although their longitudinal angle also matters. When compared to the influence of heart geometry, nexium office press only the size of the left ventricle has an impact somewhat comparable that of fiber orientation.

To help obtain the valuable fiber orientation data, Barbarotta also proposes a methodology to estimate this orientation from data that can be measured in the clinic. With this methodology, the difference between the estimated and actual fiber orientation was found to be within the mean DT-MRI measurement error of 10 degrees.

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