Firefighters have rushed to the scene in Paris to attend the blaze.
Footage on social media shows the huge cloud of smoke rising above the station.
The centre of the fire is understood to be near Gare de Lyon rather than inside.
Paris police have tweeted to say they are evacuating people from the area.
Unconfirmed reports claim the fire is related to a protest in the area.
Firefighters at the scene were also reportedly being prevented from accessing the scene by protesters, it is claimed.
Roads in the area have been closed and public transport is not running a normal service.
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